Journal Article

Multiple newly identified loci associated with prostate cancer susceptibility

Parker, Christopher C, Huddart, Robert A, Bryant, Sarah L, Jugurnauth, Sarah K, Kote-Jarai, Zsofia, Khoo, Vincent S, Mulholland, Shani, Thompson, Alan, Lewis, Sarah, Horwich, Alan, Cox, Angie, Woodhouse, Christopher J, Morrison, Jonathan, Smith, Charmaine, Southey, Melissa C, Fisher, Cyril, Jamieson, Charles, Ogden, Chris, Easton, Douglas F, Jhavar, Sameer G, English, Dallas R, Gehr-Swain, Beatrice N, Severi, Gianluca, Tymrakiewicz, Malgorzata, Christmas, Tim, Hopper, John L, Ardern-Jones, Audrey T, Bagnato, Melisa, Wilkinson, Rosemary A, Giles, Graham G, Guy, Michelle, Dearnaley, David P, Cooper, Colin S, Neal, David E, Eeles, Rosalind A, Leongamornlert, Daniel A, Muir, Kenneth R, O'Brien, Lynne T, Edwards, Stephen M, Donovan, Jenny L, Hamdy, Freddie C, Hall, Amanda L, Olama, Ali Amin Al, Field, Helen I, Brown, Paul M, Lophatananon, Artitaya

2008

Overview

Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at ≤60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X ( P = 2.7 × 10 −8 to P = 8.7 × 10 −29 ). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB , LMTK2 and KLK3 .

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: Adult / Aged / Aged, 80 and over / Agriculture / Algorithms / Animal Genetics and Genomics / Australia / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Blood / Cancer Research / Case-Control Studies / chromosome 3 / Chromosome Mapping / Chromosomes / Deoxyribonucleic acid / Developed countries / Diagnosis / DNA / Fundamental and applied biological sciences. Psychology / Gene Function / Genetic aspects / Genetic markers / Genetic Predisposition to Disease / Genetics / Genetics of eukaryotes. Biological and molecular evolution / Genomics / Genotype / Gynecology. Andrology. Obstetrics / Health aspects / Health risks / Human Genetics / Humans / letter / Male / Male genital diseases / Medical sciences / Middle Aged / Nephrology. Urinary tract diseases / Physiological aspects / Polymorphism, Single Nucleotide / Prostate cancer / Prostate-specific antigen / Prostatic Neoplasms - genetics / Quantitative Trait Loci / Risk factors / Single nucleotide polymorphisms / Single-nucleotide polymorphism / Tumors / Tumors of the urinary system / United Kingdom / Urinary tract. Prostate gland