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The Evolution of Vertebrate Toll-Like Receptors

by Rowen, Lee , Hood, Leroy E. , Kaur, Amardeep , Smith, Kelly D. , Roach, Jared C. , Unanue, Emil R. , Purcell, Maureen K. , Glusman, Gustavo , Aderem, Alan

in Animals / Anura / Base Sequence / Biological Sciences / Chickens / Computational Biology - methods / Concerted evolution / Echinoidea / Evolution / Evolution, Molecular / Evolutionary biology / Gene Components / Genetic loci / Genomes / Genomics / Genomics - methods / Invertebrates / Marine / Membrane Glycoproteins - genetics / Models, Genetic / Molecular Sequence Data / Multigene family / Multigene Family - genetics / Pathogens / Phylogeny / Pseudogenes / Receptors, Cell Surface - genetics / Sequence Analysis, DNA / Species Specificity / Takifugu / Takifugu - genetics / Takifugu rubripes / Toll-Like Receptor 1 / Toll-Like Receptors / Vertebrates / Vertebrates - genetics

2005

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The Evolution of Vertebrate Toll-Like Receptors

by Rowen, Lee , Hood, Leroy E. , Kaur, Amardeep , Smith, Kelly D. , Roach, Jared C. , Unanue, Emil R. , Purcell, Maureen K. , Glusman, Gustavo , Aderem, Alan

2005

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The Evolution of Vertebrate Toll-Like Receptors

by Rowen, Lee , Hood, Leroy E. , Kaur, Amardeep , Smith, Kelly D. , Roach, Jared C. , Unanue, Emil R. , Purcell, Maureen K. , Glusman, Gustavo , Aderem, Alan

2005

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Journal Article

The Evolution of Vertebrate Toll-Like Receptors

Rowen, Lee,

Hood, Leroy E.,

Kaur, Amardeep,

Smith, Kelly D.,

Roach, Jared C.,

Unanue, Emil R.,

Purcell, Maureen K.,

Glusman, Gustavo,

Aderem, Alan

2005

Overview

The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure for recognition of and response to pathogen-associated molecular patterns has maintained a largely unchanging TLR recognition in all vertebrates. There are six major families of vertebrate TLRs. This repertoire is distinct from that of invertebrates. TLRs within a family recognize a general class of pathogen-associated molecular patterns. Most vertebrates have exactly one gene ortholog for each TLR family. The family including TLR1 has more species-specific adaptations than other families. A major family including TLR11 is represented in humans only by a pseudogene. Coincidental evolution plays a minor role in TLR evolution. The sequencing phase of this study produced finished genomic sequences for the 12 Takifugu rubripes TLRs. In addition, we have produced >70 gene models, including sequences from the opossum, chicken, frog, dog, sea urchin, and sea squirt.

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Publisher

National Academy of Sciences,National Acad Sciences

Subject

Animals

/ Anura

/ Base Sequence

/ Biological Sciences

/ Chickens

/ Computational Biology - methods

/ Concerted evolution