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Prostate cancer: is it time to expand the research focus to early-life exposures?
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Journal Article
Prostate cancer: is it time to expand the research focus to early-life exposures?
2013
Overview
Although we understand various aspects of prostate cancer biology, few reliable risk factors are known. This Opinion article rationalizes why exposures early in life may be key for prostate cancer risk, summarizes our current limited understanding of early-life exposures and provides visions for the future.
Although the contribution of lifestyle and environment (non-genetic factors) to prostate carcinogenesis is indicated by international variation in prostate cancer occurrence and migration studies, no conclusive modifiable risk factors have yet been identified. One possible reason for this may be the dearth of epidemiological research on exposures experienced early in life, when the immature prostate may be more susceptible to carcinogenic exposures. In this Opinion article, we summarize the rationale for studying early-life exposures, describe the small body of early-life research and its associated challenges, and point to solutions for future research.
Publisher
Nature Publishing Group UK,Nature Publishing Group
