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PI3K/Akt/mTOR信号转导通路与非小细胞肺癌
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Journal Article
PI3K/Akt/mTOR信号转导通路与非小细胞肺癌
2010
Overview
肺癌是目前世界上发病率和死亡率最高的恶性肿瘤之一,其中非小细胞肺癌（non-small cell lung can-cer,NSCLC）占肺癌的75%-85%,确诊时多属中晚期,常规放、化疗效果欠佳,5年生存率仅为5%-10%。PI3K/Akt/mTOR信号通路作为细胞内重要信号转导通路之一,通过影响下游多种效应分子的活化状态,与NSCLC的发生发展密切相关。本文综述了PI3K/Akt/mTOR信号通路的组成,其抑制凋亡、促进增殖的关键作用以及在NSCLC中的研究现状,以期为NSCLC的治疗寻找潜在的靶点。
Publisher
上海交通大学附属第六人民医院呼吸内科,上海,200233
Subject
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