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The role of immunity in mosquito-induced attenuation of malaria virulence
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Journal Article
The role of immunity in mosquito-induced attenuation of malaria virulence
2014
Overview
A recent study found that mosquito-transmitted (MT) lines of rodent malaria parasites elicit a more effective immune response than non-transmitted lines maintained by serial blood passage (non-MT), thereby causing lower parasite densities in the blood and less pathology to the host. The authors attribute these changes to higher diversity in expression of antigen-encoding genes in MT cf. non-MT lines. Alternative explanations that are equally parsimonious with these new data, and results from previous studies, suggest that this conclusion may be premature.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
