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Noncoding RNAs: Possible Players in the Development of Fluorosis
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Noncoding RNAs: Possible Players in the Development of Fluorosis
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Journal Article
Noncoding RNAs: Possible Players in the Development of Fluorosis
2015
Overview
Fluorosis is caused by excess of fluoride intake over a long period of time. Aberrant change in the Runt-related transcription factor 2 (RUNX2) mediated signaling cascade is one of the decisive steps during the pathogenesis of fluorosis. Up to date, role of fluoride on the epigenetic alterations is not studied. In the present study, global expression profiling of short noncoding RNAs, in particular miRNAs and snoRNAs, was carried out in sodium fluoride (NaF) treated human osteosarcoma (HOS) cells to understand their possible role in the development of fluorosis. qPCR and in silico hybridization revealed that miR-124 and miR-155 can be directly involved in the transcriptional regulation of Runt-related transcription factor 2 (RUNX2) and receptor activator of nuclear factor κ-B ligand (RANKL) genes. Compared to control, C/D box analysis revealed marked elevation in the number of UG dinucleotides and D-box sequences in NaF exposed HOS cells. Herein, we report miR-124 and miR-155 as the new possible players involved in the development of fluorosis. We show that the alterations in UG dinucleotides and D-box sequences of snoRNAs could be due to NaF exposure.
Publisher
Hindawi Publishing Corporation,John Wiley & Sons, Inc
Subject
/ Cell Differentiation - drug effects
/ Cell Survival - drug effects
/ Core Binding Factor Alpha 1 Subunit - biosynthesis
/ Core Binding Factor Alpha 1 Subunit - genetics
/ Fluorosis, Dental - genetics
/ Fluorosis, Dental - pathology
/ Gene Expression Regulation - drug effects
/ Humans
/ Ligands
/ MicroRNA
/ Osteosarcoma - complications
/ RNA, Small Nucleolar - genetics
/ Signal Transduction - drug effects
/ Studies
