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Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

by Nojiri, Hidetoshi , Yokote, Koutaro , Izuo, Naotaka , Watanabe, Kenji , Shibuya, Shuichi , Shimizu, Takahiko , Ozawa, Yusuke

in Age / Aging / Aging - drug effects / Aging - pathology / Animals / Antioxidants / Antioxidants - pharmacology / Brain research / Cataracts / Development and progression / Ears & hearing / Enzymes / Gene expression / Genetic aspects / Health aspects / Hearing loss / Humans / Infertility / Intracellular Space - metabolism / Macular degeneration / Medicine / Mitochondria / Musculoskeletal system / Oxidation-Reduction - drug effects / Oxidative stress / Oxidoreductases / Properties / Protein deficiency / Proteins / Review / Rodents / Signal Transduction - drug effects / Skin / Superoxide Dismutase - deficiency / Superoxide Dismutase - metabolism / Superoxide Dismutase-1 / University graduates

2014

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Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

by Nojiri, Hidetoshi , Yokote, Koutaro , Izuo, Naotaka , Watanabe, Kenji , Shibuya, Shuichi , Shimizu, Takahiko , Ozawa, Yusuke

2014

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Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

by Nojiri, Hidetoshi , Yokote, Koutaro , Izuo, Naotaka , Watanabe, Kenji , Shibuya, Shuichi , Shimizu, Takahiko , Ozawa, Yusuke

2014

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Journal Article

Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

Nojiri, Hidetoshi,

Yokote, Koutaro,

Izuo, Naotaka,

Watanabe, Kenji,

Shibuya, Shuichi,

Shimizu, Takahiko,

Ozawa, Yusuke

2014

Overview

Aging is characterized by increased oxidative stress, chronic inflammation, and organ dysfunction, which occur in a progressive and irreversible manner. Superoxide dismutase (SOD) serves as a major antioxidant and neutralizes superoxide radicals throughout the body. In vivo studies have demonstrated that copper/zinc superoxide dismutase-deficient (Sod1−/−) mice show various aging-like pathologies, accompanied by augmentation of oxidative damage in organs. We found that antioxidant treatment significantly attenuated the age-related tissue changes and oxidative damage-associated p53 upregulation in Sod1−/− mice. This review will focus on various age-related pathologies caused by the loss of Sod1 and will discuss the molecular mechanisms underlying the pathogenesis in Sod1−/− mice.

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Publisher

Hindawi Publishing Corporation,John Wiley & Sons, Inc

Subject

Age

/ Aging

/ Aging - drug effects

/ Aging - pathology

/ Animals

/ Antioxidants

/ Antioxidants - pharmacology