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Regulatory Role of Small Nucleolar RNAs in Human Diseases
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Journal Article
Regulatory Role of Small Nucleolar RNAs in Human Diseases
2015
Overview
Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in human cells. The canonical function of box C/D and box H/ACA snoRNAs is posttranscriptional modification of ribosomal RNAs (rRNAs), namely, 2′-O-methylation and pseudouridylation, respectively. A series of independent studies demonstrated that snoRNAs, as well as other noncoding RNAs, serve as the source of various short regulatory RNAs. Some snoRNAs and their fragments can also participate in the regulation of alternative splicing and posttranscriptional modification of mRNA. Alterations in snoRNA expression in human cells can affect numerous vital cellular processes. SnoRNA level in human cells, blood serum, and plasma presents a promising target for diagnostics and treatment of human pathologies. Here we discuss the relation between snoRNAs and oncological, neurodegenerative, and viral diseases and also describe changes in snoRNA level in response to artificial stress and some drugs.
Publisher
Hindawi Publishing Corporation,John Wiley & Sons, Inc
Subject
/ Boxes
/ Diseases
/ Heredodegenerative Disorders, Nervous System - genetics
/ Heredodegenerative Disorders, Nervous System - metabolism
/ Humans
/ Proteins
/ Review
/ RNA
/ RNA Processing, Post-Transcriptional
/ RNA, Small Nucleolar - chemistry
/ RNA, Small Nucleolar - genetics
