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Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development
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Journal Article
Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development
2007
Overview
New tools for controlling tuberculosis are urgently needed. Despite our emerging understanding of the biogeography of
Mycobacterium tuberculosis, the implications for development of new diagnostics, drugs, and vaccines is unknown.
M tuberculosis has a clonal genetic population structure that is geographically constrained. Evidence suggests strain-specific differences in virulence and immunogenicity in light of this global phylogeography. We propose a strain selection framework, based on robust phylogenetic markers, which will allow for systematic and comprehensive evaluation of new tools for tuberculosis control.
Publisher
Elsevier Ltd,Lancet Publishing Group,Elsevier Limited
