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The plasma proteomic signature as a strategic tool for early diagnosis of acute coronary syndrome
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The plasma proteomic signature as a strategic tool for early diagnosis of acute coronary syndrome
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Journal Article
The plasma proteomic signature as a strategic tool for early diagnosis of acute coronary syndrome
2014
Overview
Background
Acute coronary syndrome is the major cause of death in developed countries. Despite its high prevalence, there is still a strong need for new biomarkers which permit faster and more accurate diagnostics and new therapeutic drugs. The basis for this challenge lay in improving our understanding of the whole atherosclerotic process from atherogenesis to atherothrombosis. In this study, we conducted two different proteomic analyses of peripheral blood plasma from non-ST elevation acute coronary syndrome and ST elevation acute coronary syndrome patients
vs
healthy controls.
Results
Two-dimensional Fluorescence Difference in Gel Electrophoresis and mass spectrometry permitted the identification of 31 proteins with statistical differences (p < 0.05) between experimental groups. Additionally, validation by Western blot and Selected Reaction Monitoring permitted us to confirm the identification of a different and characteristic plasma proteomic signature for NSTEACS and STEACS patients.
Conclusions
We purpose the severity of hypoxia as the cornerstone for explaining the differences observed between both groups.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
