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Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

by de Boer, Jan , Barradas, Ana M. C. , de Bruijn, Joost D. , Yuan, Huipin , de Ruiter, Ad , Walsh, William R. , Langer, Robert , Fernandes, Hugo , van Blitterswijk, Clemens A. , Habibovic, Pamela

in Animals / Autologous transplantation / Biocompatible Materials / Bioengineering / Biological Sciences / Biomaterials / Biomedical materials / Bone formation / Bone surgery / Bone Transplantation / Bones / Calcium / Calcium phosphates / Calcium Phosphates - pharmacology / Cell differentiation / Cell Differentiation - drug effects / Ceramic materials / Ceramics / Histology / Humans / Microscopy, Electron, Scanning / Osteogenesis - drug effects / Physical Sciences / Porous materials / Sheep / Stem cells / Stem Cells - cytology / Stem Cells - drug effects / texture / Tissue engineering / Tissue grafting / Transplantation, Autologous

2010

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Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

by de Boer, Jan , Barradas, Ana M. C. , de Bruijn, Joost D. , Yuan, Huipin , de Ruiter, Ad , Walsh, William R. , Langer, Robert , Fernandes, Hugo , van Blitterswijk, Clemens A. , Habibovic, Pamela

2010

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Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

by de Boer, Jan , Barradas, Ana M. C. , de Bruijn, Joost D. , Yuan, Huipin , de Ruiter, Ad , Walsh, William R. , Langer, Robert , Fernandes, Hugo , van Blitterswijk, Clemens A. , Habibovic, Pamela

2010

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Journal Article

Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

de Boer, Jan,

Barradas, Ana M. C.,

de Bruijn, Joost D.,

Yuan, Huipin,

de Ruiter, Ad,

Walsh, William R.,

Langer, Robert,

Fernandes, Hugo,

van Blitterswijk, Clemens A.,

Habibovic, Pamela

2010

Overview

Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used to treat small bone defects but in general do not induce stem cell differentiation, which is essential for regenerating large bone defects. Here, we prepared calcium phosphate ceramics with varying physicochemical and structural characteristics. Microporosity correlated to their propensity to stimulate osteogenic differentiation of stem cells in vitro and bone induction in vivo. Implantation in a large bone defect in sheep unequivocally demonstrated that osteoinductive ceramics are equally efficient in bone repair as autologous bone grafts. Our results provide proof of concept for the clinical application of \"smart\" biomaterials.

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Publisher

National Academy of Sciences,National Acad Sciences

Subject

Animals

/ Autologous transplantation

/ Biocompatible Materials

/ Bioengineering

/ Biological Sciences

/ Biomaterials

/ Biomedical materials