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Quorum Sensing Inhibition by Marine Bacteria
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Journal Article
Quorum Sensing Inhibition by Marine Bacteria
2019
Overview
Antibiotic resistance has been increasingly reported for a wide variety of bacteria of clinical significance. This widespread problem constitutes one of the greatest challenges of the twenty-first century. Faced with this issue, clinicians and researchers have been persuaded to design novel strategies in order to try to control pathogenic bacteria. Therefore, the discovery and elucidation of the mechanisms underlying bacterial pathogenesis and intercellular communication have opened new perspectives for the development of alternative approaches. Antipathogenic and/or antivirulence therapies based on the interruption of quorum sensing pathways are one of several such promising strategies aimed at disarming rather than at eradicating bacterial pathogens during the course of colonization and infection. This review describes mechanisms of bacterial communication involved in biofilm formation. An overview of the potential of marine bacteria and their bioactive components as QS inhibitors is further provided.
Publisher
MDPI AG,MDPI
Subject
Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ antipathogenic and antivirulence
/ Aquatic Organisms - immunology
/ Aquatic Organisms - metabolism
/ Bacteria
/ Bacterial Infections - drug therapy
/ Bacterial Infections - microbiology
/ biofilm
/ Biofilms
/ Biological Products - immunology
/ Biological Products - metabolism
/ Biological Products - therapeutic use
/ Drug Resistance, Microbial - drug effects
/ E coli
/ Humans
/ Peptides
/ Proteins
/ Quorum Sensing - drug effects
/ Review
