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地塞米松对低氧小鼠缺氧诱导因子-1α及血管内皮生长因子表达的影响
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Journal Article
地塞米松对低氧小鼠缺氧诱导因子-1α及血管内皮生长因子表达的影响
2006
Overview
背景与目的业已发现缺氧与肿瘤发生、发展关系密切。本研究的目的是观察地塞米松对低氧小鼠肺组织中缺氧诱导因子-1α（hypoxia inducible factor 1α，HIF-1α）及血管内皮生长因子（vascular endothelial growth factor，VEGF）表达的影响，探讨缺氧与血管新生的关系及地塞米松的作用机制。方法实验用雄性昆明小鼠，随机分为对照组和三个实验组（缺氧3天组、缺氧6天组、缺氧＋激素组）。用免疫组织化学技术检测小鼠肺组织中HIF-1α和VEGF蛋白的表达。结果缺氧组小鼠HIF-1α和VEGF蛋白表达均较对照组显著增加（P〈0．05）；缺氧＋激素组与缺氧组比较，HIF-1α和VEGF蛋白表达显著下降（P〈0．05）。HIF-1α与VEGF表达呈正相关（r=0．730，P=0．007）。结论缺氧可以上调小鼠肺组织中VEGF和HIF-1α的表达，而地塞米松可抑制低氧小鼠VEGF和HIF-1α的表达，具有抗血管生成的作用。
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