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Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi
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Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi
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Journal Article
Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi
2010
Overview
In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC50 values of 3.17 and 3.21 μM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.
Publisher
MDPI AG,Molecular Diversity Preservation International
Subject
/ Anthraquinones - isolation & purification
/ Anthraquinones - pharmacology
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - isolation & purification
/ Antineoplastic Agents - pharmacology
/ Drug Screening Assays, Antitumor
/ Fungi - isolation & purification
/ Humans
/ KB Cells
