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The prognostic value of tumour–stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review
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The prognostic value of tumour–stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review
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Journal Article
The prognostic value of tumour–stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review
2019
Overview
PurposeThere is a strong need to improve the prognostication of breast cancer patients in order to prevent over- and undertreatment, especially when considering adjuvant chemotherapy. Tumour stroma characteristics might be valuable in predicting disease progression.MethodsStudies regarding the prognostic value of tumour–stroma ratio (TSR) in breast cancer are evaluated.ResultsA high stromal content is related to a relatively poor prognosis. The most pronounced prognostic effect of this parameter seems to be observed in the triple-negative breast cancer (TNBC) subtype.ConclusionsTSR assessment might represent a simple, fast and reproducible prognostic factor at no extra costs, and could possibly be incorporated into routine pathological diagnostics. Despite these advantages, a robust clinical validation of this parameter has yet to be established in prospective studies.
Publisher
Springer Nature B.V
Subject
