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精神分裂症circRNA的差异表达及其与症状的关系
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精神分裂症circRNA的差异表达及其与症状的关系
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Journal Article
精神分裂症circRNA的差异表达及其与症状的关系
2017
Overview
目的探讨精神分裂症circRNA表达水平及其与患者阴性、阳性症状的关系。方法分别选取5例精神分裂症患者和正常人外周血进行基因芯片筛查,确定9种存在差异表达的circRNA,并在102例精神分裂症患者和103例正常人中进行PCR验证,进一步行精神分裂症阳性和阴性症状量表评估。结果精神分裂症患者外周血circRNA_102101、circRNA_102315、circRNA_104597、circRNA_101835、circRNA_101836的表达水平明显下调（P〈0.05或P〈0.01）。circRNA_103102、circRNA_103704的表达水平明显上调（P〈0.01）。circRNA_102101、circRNA_103102的ΔCt值与阳性症状呈明显正相关（P〈0.01或P〈0.05）。circRNA_103704与阳性症状、一般精神病理呈明显正相关（P〈0.01或P〈0.05）。思维障碍与circRNA_102101、circRNA_103102、circRNA_102315、circRNA_103704、circRNA_102802的ΔCt值呈明显正相关（P〈0.01或P〈0.05）。激活性与circRNA_102101、circRNA_103102、circRNA_104597、circRNA_103704、circRNA_102802的ΔCt值呈明显正相关（P〈0.01或P〈0.05）。偏执与circRNA_102101、circRNA_103102、ci rcRNA_103704、ci rcRNA_102802的ΔCt值呈明显正相关（P〈0.01或P〈0.05）。攻击性与ci rcRNA_102101、circRNA_103102、circRNA_103704、circRNA_102802的ΔCt值呈明显正相关（P〈0.01或P〈0.05）。circRNA_103704进入阳性症状的回归方程（P〈0.01）;circRNA_103704、circRNA_102315进入一般病理表现的回归方程（P〈0.01或P〈0.05）。结论circRNA_103704、circRNA_103102与精神分裂症阴性、阳性症状有明显关联,可能是精神分裂症病理过程主导的调控因子。
Publisher
213003,江苏常州 解放军102医院全军心理疾病防治中心
Subject
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