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白细胞介素和基质金属蛋白酶对颈动脉粥样硬化斑块易损性及脑梗死的影响
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白细胞介素和基质金属蛋白酶对颈动脉粥样硬化斑块易损性及脑梗死的影响
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Journal Article
白细胞介素和基质金属蛋白酶对颈动脉粥样硬化斑块易损性及脑梗死的影响
2012
Overview
目的探讨炎细胞因子白细胞介素－17、－10（IL－17、IL－10）和基质金属蛋白酶－12（MMP－12）与颈动脉粥样硬化斑块易损性及脑梗死的关系。方法根据临床卒中事件将70例患者分为无症状性颈动脉粥样硬化（ACAS）组和急性动脉粥样硬化性脑梗死（AACI）组，并根据颈部血管彩色超声结果分为易损性斑块组和非易损性斑块组，酶联免疫吸附试验测定各组受试者血清IL－17、IL－10和MMP－12水平。结果各组患者血清IL—17、IL－10及MMP－12表达水平比较，差异均有统计学意义（P=0．000）。其中AACI组患者血清IL－17及MMP－12分别高于ACAS组和正常对照组（均P=0．000），而AACI组患者血清IL－10表达水平低于正常对照组和ACAS组（均P=0．000），后两组之间差异无统计学意义（P=0．275）。易损性斑块组患者血清IL－17和MMP－12表达水平高于非易损性斑块组（P：0．000，P=0．014），而血清IL－10表达水平低于非易损性斑块组和正常对照组（P=0．000），后两组之间差异无统计学意义（P=0．742）。相关分析显示，血清IL．17表达水平与MMP．12呈正相关（r=0．640，P=0．000）、与IL－10呈负相关（r＝－0．430，P=0．000），MMP－12与IL－10之间呈负相关（r=－0．242，P=0．013）。结论IL－17、IL－10及MMP－12均参与了动脉粥样硬化及其脑梗死的病理过程，IL－17、MMP－12水平升高及IL．10水平下降与斑块易损性密切相关，其结果有助于临床早期发现动脉粥样硬化斑块的易损性及预测急性缺血性脑卒中事件的发生。
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