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Genetic control of single lumen formation in the zebrafish gut
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Genetic control of single lumen formation in the zebrafish gut
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Journal Article
Genetic control of single lumen formation in the zebrafish gut
2007
Overview
Most organs consist of networks of interconnected tubes that serve as conduits to transport fluid and cells and act as physiological barriers between compartments. Biological tubes are assembled through very diverse developmental processes that generate structures of different shapes and sizes. Nevertheless, all biological tubes invariably possess one single lumen. The mechanisms responsible for single lumen specification are not known. Here we show that zebrafish mutants for the MODY5 and familial GCKD gene
tcf2
(also known as
vhnf1
) fail to specify a single lumen in their gut tube and instead develop multiple lumens. We show that Tcf2 controls single lumen formation by regulating
claudin15
and Na
+
/K
+
-ATPase expression. Our
in vivo
and
in vitro
results indicate that Claudin15 functions in paracellular ion transport to specify single lumen formation. This work shows that single lumen formation is genetically controlled and appears to be driven by the accumulation of fluid.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals, Genetically Modified
/ Biomedical and Life Sciences
/ Claudins
/ Conduits
/ Genes
/ Hepatocyte Nuclear Factor 1-beta - genetics
/ Hepatocyte Nuclear Factor 1-beta - metabolism
/ Intestines - anatomy & histology
/ Kinases
/ letter
/ Membrane Proteins - metabolism
/ Proteins
/ Sodium-Potassium-Exchanging ATPase - metabolism
/ Zebrafish - anatomy & histology
