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益气活血开窍复方对缺血再灌注脑组织兴奋性氨基酸及超微结构的影响
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益气活血开窍复方对缺血再灌注脑组织兴奋性氨基酸及超微结构的影响
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Journal Article
益气活血开窍复方对缺血再灌注脑组织兴奋性氨基酸及超微结构的影响
2002
Overview
目的 探讨益气活血开窍复方对缺血再灌注脑组织保护作用的机理。方法 以线栓法制备大鼠脑缺血再灌注模型，采用全自动氨基酸分析仪、干湿重法、原子吸收分光光度计测量脑组织中兴奋性氨基酸（EAA）含量、含水量及钙离子（Ca^2+）含量，电子显微镜观察脑组织超微结构改变。结果 中药组谷氨酸（Glu)含量下降（P＜0．01），谷氨酸／γ氨基丁酸（Glu/GABA)趋向于正常比值，脑组织含水量及Ca^2+浓度下降（P＜0．05）。中药可减轻由于缺血再灌注所导致的细胞超微结构的改变。结论 益气活血开窍方通过抑制EAA释放、Ca^2+内流而发挥脑组织保护作用。
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