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Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris
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Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris
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Journal Article
Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris
2018
Overview
Candida
spp
.
infections are a major cause of morbidity and mortality in critically ill patients.
Candida auris
is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents of hospital-associated infections. Independent and simultaneous outbreaks of
C. auris
are becoming a major concern for healthcare and scientific community. Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans
Candida
species, result in difficult eradication and frequent therapeutic failures of
C. auris
infections. The aim of this review was to provide an updated and comprehensive report of the global spread of
C. auris
, focusing on clinical and microbiological characteristics, mechanisms of virulence and antifungal resistance, and efficacy of available control, preventive, and therapeutic strategies.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
