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Endothelial dysfunction in cardiovascular disease and Flammer syndrome—similarities and differences
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Journal Article
Endothelial dysfunction in cardiovascular disease and Flammer syndrome—similarities and differences
2017
Overview
The endothelium has increasingly been recognized as a smart barrier and a key regulator of blood flow in micro- and macrovascular beds. Endothelial dysfunction marks a stage of atherosclerosis and is an important prognostic marker for cardiovascular disease. Yet, some people who tend to be slim and physically active and with rather low blood pressure show a propensity to respond to certain stimuli such as emotional stress with endothelial-mediated vascular dysregulation (Flammer syndrome). This leads to characteristic vascular symptoms such as cold hands but also a risk for vascular-mediated diseases such as normal-tension glaucoma. It is the aim of this review to delineate the differences between Flammer syndrome and its “counterpart” endothelial dysfunction in the context of cardiovascular diseases.
Publisher
Springer Nature B.V
Subject
