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纳洛酮对大鼠局灶性脑缺血再灌注损伤的保护作用
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Journal Article
纳洛酮对大鼠局灶性脑缺血再灌注损伤的保护作用
2003
Overview
目的 观察纳洛酮对大鼠局灶性脑缺血再灌注损伤的保护作用。方法 用改良Longa法制作局灶性脑缺血再灌注损伤模型，观察不同剂量纳洛酮对模型大鼠神经功能障碍、脑梗死范围、脑组织病理改变以及血清中乳酸脱氢酶(LDH)和肌酸激酶(CK)含量的影响。结果 纳洛酮能剂量依赖性地降低模型大鼠的血清LDH、CK，减少梗死面积。降低神经功能行为评分，减轻脑组织病理改变。结论 纳洛酮对大鼠局灶性脑缺血再灌注损伤有一定的保护作用。
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