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A cuttlefish ink nanoparticle-reinforced biopolymer hydrogel with robust adhesive and immunomodulatory features for treating oral ulcers in diabetes
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A cuttlefish ink nanoparticle-reinforced biopolymer hydrogel with robust adhesive and immunomodulatory features for treating oral ulcers in diabetes
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Journal Article
A cuttlefish ink nanoparticle-reinforced biopolymer hydrogel with robust adhesive and immunomodulatory features for treating oral ulcers in diabetes
2024
Overview
Oral ulcers can be managed using a variety of biomaterials that deliver drugs or cytokines. However, many patients experience minimal benefits from certain medical treatments because of poor compliance, short retention times in the oral cavity, and inadequate drug efficacy. Herein, we present a novel hydrogel patch (SCE2) composed of a biopolymer matrix (featuring ultraviolet-triggered adhesion properties) loaded with cuttlefish ink nanoparticles (possessing pro-healing functions). Applying a straightforward local method initiates the formation of a hydrogel barrier that adheres to mucosal injuries under the influence of ultraviolet light. SCE2 then demonstrates exceptional capabilities for near-infrared photothermal sterilization and neutralization of reactive oxygen species. These properties contribute to the elimination of bacteria and the management of the oxidation process, thus accelerating the healing phase's progression from inflammation to proliferation. In studies involving diabetic rats with oral ulcers, the SCE2 adhesive patch significantly quickens recovery by altering the inflamed state of the injured area, facilitating rapid re-epithelialization, and fostering angiogenesis. In conclusion, this light-sensitive hydrogel patch offers a promising path to expedited wound healing, potentially transforming treatment strategies for clinical oral ulcers.
We present a hydrogel patch (SCE2) endowed with strong adhesive properties and immunomodulatory functions, designed for the treatment of oral ulcers in diabetes. [Display omitted]
•A hydrogel patch (SCE2) is engineered for treating oral ulcers in individuals with diabetes.•SCE2 is produced through the incorporation of cuttlefish ink nanoparticles within a biopolymer matrix.•SCE2 demonstrates potent capabilities in photothermal antibacterial and ROS scavenging.•SCE2 aids in the recovery of oral ulcers by diminishing inflammation and enhancing angiogenesis.
Publisher
Elsevier B.V,KeAi Publishing Communications Ltd,KeAi Publishing,KeAi Communications Co., Ltd
Subject
