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Life history trade-offs in cancer evolution

by Gatenby, Robert A. , Boddy, Amy M. , Brown, Joel S. , Maley, Carlo C. , Aktipis, C. Athena

in 59/57 / 631/208/182 / 631/67/1059 / 631/67/70 / 631/67/71 / 64/60 / Animals / Biological Evolution / Biomedicine / Cancer Research / Cell Proliferation / Cell Survival / Disease Progression / Genetic aspects / Humans / Identification and classification / Indexing in process / Models, Biological / Neoplasms - metabolism / Neoplasms - pathology / Neoplasms - therapy / Neoplastic processes / opinion-2 / Phenotype / Tumor Microenvironment

2013

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Life history trade-offs in cancer evolution

by Gatenby, Robert A. , Boddy, Amy M. , Brown, Joel S. , Maley, Carlo C. , Aktipis, C. Athena

2013

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Life history trade-offs in cancer evolution

by Gatenby, Robert A. , Boddy, Amy M. , Brown, Joel S. , Maley, Carlo C. , Aktipis, C. Athena

2013

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Journal Article

Life history trade-offs in cancer evolution

Gatenby, Robert A.,

Boddy, Amy M.,

Brown, Joel S.,

Maley, Carlo C.,

Aktipis, C. Athena

2013

Overview

Evolutionary life history theory posits that some organisms reproduce rapidly whereas others invest more resources in survival. This framework might help us to understand the diversity of phenotypes that are displayed by tumour cells, including stem cell-like phenotypes, and could have important clinical implications. Somatic evolution during cancer progression and therapy results in tumour cells that show a wide range of phenotypes, which include rapid proliferation and quiescence. Evolutionary life history theory may help us to understand the diversity of these phenotypes. Fast life history organisms reproduce rapidly, whereas those with slow life histories show less fecundity and invest more resources in survival. Life history theory also provides an evolutionary framework for phenotypic plasticity, which has potential implications for understanding 'cancer stem cells'. Life history theory suggests that different therapy dosing schedules might select for fast or slow life history cell phenotypes, with important clinical consequences.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 64/60

/ Animals