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A higher incidence of smooth endoplasmic reticulum clusters with aromatase inhibitors
by
Hayashi, Nobuyoshi
, Habara, Toshihiro
, Otsuki, Junko
, Saito, Hiroe
, Hirata, Rei
, Takahashi, Hiromi
in
Age
/ Antagonists
/ Aromatase
/ aromatase inhibitor
/ Citric acid
/ Clinical outcomes
/ Clomiphene
/ clomiphene citrate
/ Comparative analysis
/ Embryos
/ Endoplasmic reticulum
/ Estradiol
/ Estrogen
/ Oocytes
/ Original
/ Progesterone
/ smooth endoplasmic reticulum
/ Statistical analysis
/ Studies
2019
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A higher incidence of smooth endoplasmic reticulum clusters with aromatase inhibitors
by
Hayashi, Nobuyoshi
, Habara, Toshihiro
, Otsuki, Junko
, Saito, Hiroe
, Hirata, Rei
, Takahashi, Hiromi
in
Age
/ Antagonists
/ Aromatase
/ aromatase inhibitor
/ Citric acid
/ Clinical outcomes
/ Clomiphene
/ clomiphene citrate
/ Comparative analysis
/ Embryos
/ Endoplasmic reticulum
/ Estradiol
/ Estrogen
/ Oocytes
/ Original
/ Progesterone
/ smooth endoplasmic reticulum
/ Statistical analysis
/ Studies
2019
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While trying to remove the title from your shelf something went wrong :( Kindly try again later!
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A higher incidence of smooth endoplasmic reticulum clusters with aromatase inhibitors
by
Hayashi, Nobuyoshi
, Habara, Toshihiro
, Otsuki, Junko
, Saito, Hiroe
, Hirata, Rei
, Takahashi, Hiromi
in
Age
/ Antagonists
/ Aromatase
/ aromatase inhibitor
/ Citric acid
/ Clinical outcomes
/ Clomiphene
/ clomiphene citrate
/ Comparative analysis
/ Embryos
/ Endoplasmic reticulum
/ Estradiol
/ Estrogen
/ Oocytes
/ Original
/ Progesterone
/ smooth endoplasmic reticulum
/ Statistical analysis
/ Studies
2019
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A higher incidence of smooth endoplasmic reticulum clusters with aromatase inhibitors
Journal Article
A higher incidence of smooth endoplasmic reticulum clusters with aromatase inhibitors
2019
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Overview
Purpose
This study aimed to analyze whether a regimen of aromatase inhibitor (AI) could reduce the occurrence of smooth endoplasmic reticulum clusters (sERCs) in oocytes.
Method(s)
The AI and the clomiphene citrate (CC) regimens were compared, regarding the sERC (+) rates and the serum estradiol and progesterone levels on the date of hCG administration, and the duration of AI, CC, and hMG administration.
Result(s)
The occurrence of sERCs in oocytes from patients treated with AI was significantly higher than that in oocytes from those treated with CC. Both the serum estradiol and progesterone levels were found to be significantly higher in sERC (+) than in sERC (‐) cycles. With regard to the CC cycles, no significant differences were detected. The duration of AI and hMG administration was longer for sERC (+) than for sERC (‐) cycles.
Conclusion
As AI did not reduce the occurrence of sERCs, the elevation of estradiol may not be the cause of sERC occurrence but a consequence. Considering the higher levels of progesterone and longer duration of hMG in sERC (+) cycles, the negative effects of premature luteinization, which frequently occur with the AI protocol, should be investigated further.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
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