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Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis
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Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis
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Journal Article
Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis
2009
Overview
The
fibroblast growth factor receptor 4
(
FGFR4
) is thought to be involved in many critical cellular processes and has been associated with prostate cancer risk. Four single nucleotide polymorphisms (SNPs) within or near
FGFR4
were analyzed in a population-based study of 1458 prostate cancer patients and 1352 age-matched controls. We found no evidence to suggest that any of the
FGFR4
SNP genotypes were associated with prostate cancer risk or with disease aggressiveness, Gleason score or stage. A weak association was seen between rs351855 and prostate cancer-specific mortality. Subset analysis of cases that had undergone radical prostatectomy revealed an association between rs351855 and prostate cancer risk. Although our results confirm an association between
FGFR4
and prostate cancer risk in radical prostatectomy cases, they suggest that the role of
FGFR4
in disease risk and outcomes at a population-based level appears to be minor.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Biomarkers, Tumor - genetics
/ Biomedical and Life Sciences
/ Fibroblast growth factor receptor 4
/ Fibroblast growth factor receptors
/ Genetic Predisposition to Disease
/ Humans
/ Male
/ Polymorphism, Single Nucleotide
/ Prostatic Neoplasms - genetics
/ Prostatic Neoplasms - surgery
/ Receptor, Fibroblast Growth Factor, Type 4 - genetics
/ Risk
