Asset Details
Do you wish to reserve the book?
The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
Do you wish to request the book?
The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
2021
Overview
Kidney disease progression can be affected by Na
+
abundance. A key regulator of Na
+
homeostasis is the ubiquitin ligase NEDD4-2 and its deficiency leads to increased Na
+
transport activity and salt-sensitive progressive kidney damage. However, the mechanisms responsible for high Na
+
induced damage remain poorly understood. Here we show that a high Na
+
diet compromised kidney function in
Nedd4-2
-deficient mice, indicative of progression toward end-stage renal disease. Injury was characterized by enhanced tubule dilation and extracellular matrix accumulation, together with sustained activation of both Wnt/β-catenin and TGF-β signaling.
Nedd4-2
knockout in cortical collecting duct cells also activated these pathways and led to epithelial–mesenchymal transition. Furthermore, low dietary Na
+
rescued kidney disease in
Nedd4-2
-deficient mice and silenced Wnt/β-catenin and TGF-β signaling. Our study reveals the important role of NEDD4-2-dependent ubiquitination in Na
+
homeostasis and protecting against aberrant Wnt/β-catenin/TGF-β signaling in progressive kidney disease.
Publisher
Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
Subject
/ 13/95
/ 64
/ 64/60
/ 96
/ 96/95
/ Animals
/ Biomedical and Life Sciences
/ Endosomal Sorting Complexes Required for Transport - metabolism
/ Kidney Failure, Chronic - metabolism
/ Kidney Failure, Chronic - prevention & control
/ Nedd4 Ubiquitin Protein Ligases - metabolism
