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Graves’病样自然杀伤T细胞缺如小鼠血清TSH受体抗体的水平
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Journal Article
Graves’病样自然杀伤T细胞缺如小鼠血清TSH受体抗体的水平
2003
Overview
目的 探讨自然杀伤T细胞(natural killer T cell,NK T)在Graves''病发病中的作用。方法 用表达有人TSH受体的细胞免疫NKT细胞缺如小鼠和野生型BLAB/c小鼠，每两周一次，共6次。在最后一次免疫结束后两周处死小鼠，检测血清甲状腺素水平，TSH受体抗体。结果 免疫后的NKT细胞缺如小鼠，血清TT4和TRAb水平轻度升高，并且与对照组比较，有显著性差异。但是，在经免疫的NKT细胞缺如小鼠和野生型小鼠之间，血清平均TT4水平和TRAb水平相似，且TSAb与TSBAb水平变化两组之间无显著性差异。结论 NKT细胞可能不参与Graves'病的发生。
