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The apelinergic system as an alternative to catecholamines in low-output septic shock
by
Dumont, Lauralyne
, Lesur, Olivier
, Sainsily, Xavier
, Coquerel, David
, Marsault, Éric
, Sarret, Philippe
, Auger-Messier, Mannix
in
Apelin (APJ) receptor
/ Apelinergic system
/ Biased signaling
/ Catecholamines
/ Control
/ Critical Care Medicine
/ Decatecholaminization
/ Emergency Medicine
/ Health aspects
/ Homeostasis
/ Inodilator
/ Intensive
/ Medicine
/ Medicine & Public Health
/ Septic shock
/ Viewpoint
2018
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The apelinergic system as an alternative to catecholamines in low-output septic shock
by
Dumont, Lauralyne
, Lesur, Olivier
, Sainsily, Xavier
, Coquerel, David
, Marsault, Éric
, Sarret, Philippe
, Auger-Messier, Mannix
in
Apelin (APJ) receptor
/ Apelinergic system
/ Biased signaling
/ Catecholamines
/ Control
/ Critical Care Medicine
/ Decatecholaminization
/ Emergency Medicine
/ Health aspects
/ Homeostasis
/ Inodilator
/ Intensive
/ Medicine
/ Medicine & Public Health
/ Septic shock
/ Viewpoint
2018
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The apelinergic system as an alternative to catecholamines in low-output septic shock
by
Dumont, Lauralyne
, Lesur, Olivier
, Sainsily, Xavier
, Coquerel, David
, Marsault, Éric
, Sarret, Philippe
, Auger-Messier, Mannix
in
Apelin (APJ) receptor
/ Apelinergic system
/ Biased signaling
/ Catecholamines
/ Control
/ Critical Care Medicine
/ Decatecholaminization
/ Emergency Medicine
/ Health aspects
/ Homeostasis
/ Inodilator
/ Intensive
/ Medicine
/ Medicine & Public Health
/ Septic shock
/ Viewpoint
2018
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The apelinergic system as an alternative to catecholamines in low-output septic shock
Journal Article
The apelinergic system as an alternative to catecholamines in low-output septic shock
2018
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Overview
Catecholamines, in concert with fluid resuscitation, have long been recommended in the management of septic shock. However, not all patients respond positively and controversy surrounding the efficacy-to-safety profile of catecholamines has emerged, trending toward decatecholaminization. Contextually, it is time to re-examine the “maintaining blood pressure” paradigm by identifying safer and life-saving alternatives. We put in perspective the emerging and growing knowledge on a promising alternative avenue: the apelinergic system. This target exhibits invaluable pleiotropic properties, including inodilator activity, cardio-renal protection, and control of fluid homeostasis. Taken together, its effects are expected to be greatly beneficial for patients in septic shock.
Publisher
BioMed Central,BioMed Central Ltd,BMC
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