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De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report
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De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report
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Journal Article
De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report
2021
Overview
Background
Apart from Kasai’s procedure, liver transplantation (LTx) has dramatically improved the outcome of children with biliary atresia (BA). However, de novo malignancy has been reported to be one of the major causes of late mortality after LTx among adults. We report a rare case of de novo gastric cancer developing after LTx for BA received during childhood.
Case presentation
A 21-year-old male patient who had undergone LTx for BA at age 2 years occasionally visited our outpatient clinic due to symptoms of epigastric pain and dysphagia. Endoscopic examination and computed tomography revealed advanced gastric cancer at the gastroesophageal junction with multiple liver metastases. Despite systemic chemotherapy, the disease progressed, resulting in patient’s death 2 years after the diagnosis.
Conclusions
De novo malignancy in the absence of post-transplant lymphoproliferative disease is rare in pediatric patients who received LTx. To the best of our knowledge, no report has been available on the development of gastric cancer after LTx for BA during childhood. Primary physicians should therefore establish a follow-up plan for patients receiving LTx for BA considering the potential for the development of de novo malignancy, including gastric cancer, despite its rarity.
Publisher
Springer Science and Business Media LLC,Springer Berlin Heidelberg,International Academic Publishing Co Ltd,Japan Surgical Society
