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The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9
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The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9
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Journal Article
The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9
2016
Overview
Tumor cells commonly express abnormally glycosylated glycoproteins such as MUC1. Burchell and colleagues show that tumor-specific MUC1-ST interacts with the lectin Siglec-9 on myeloid cells and induces their conversion into suppressive tumor-associated macrophages.
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expressed on cancer cells, it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Here we found that this cancer-specific MUC1 glycoform, through engagement of Siglec-9, ‘educated’ myeloid cells to release factors associated with determination of the tumor microenvironment and disease progression. Moreover, MUC1-ST induced macrophages to display a tumor-associated macrophage (TAM)-like phenotype, with increased expression of the checkpoint ligand PD-L1. Binding of MUC1-ST to Siglec-9 did not activate the phosphatases SHP-1 or SHP-2 but, unexpectedly, induced calcium flux that led to activation of the kinases MEK-ERK. This work defines a critical role for aberrantly glycosylated MUC1 and identifies an activating pathway that follows engagement of Siglec-9.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 13/1
/ 13/106
/ 13/31
/ 13/95
/ 82/79
/ Dendritic Cells - immunology
/ Dendritic Cells - metabolism
/ Extracellular Signal-Regulated MAP Kinases - metabolism
/ Humans
/ Lectins
/ Mitogen-Activated Protein Kinases - metabolism
/ Mucins
/ Sialic Acid Binding Immunoglobulin-like Lectins - genetics
/ Sialic Acid Binding Immunoglobulin-like Lectins - metabolism
