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A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

by Carvajal-Carmona, Luis , Rowan, Andrew , Lubbe, Steven , Houlston, Richard S , Webb, Emily , Gray, Richard , Peto, Julian , Fielding, Sarah , Spain, Sarah , Qureshi, Mobshra , Barclay, Ella , Sieber, Oliver , Gorman, Maggie , Papaemmanuil, Elli , Tomlinson, Ian , Cazier, Jean-Baptiste , Sullivan, Kate , Jaeger, Emma , Wood, Wendy , Howarth, Kimberley , Penegar, Steven , Martin, Lynn , Domingo, Enric , Pittman, Alan M , Vijayakrishnan, Jayaram , Kerr, David , Broderick, Peter , Sellick, Gabrielle , Kemp, Zoe , Chandler, Ian , Teixeira, Ana

in Agriculture / Alleles / Animal Genetics and Genomics / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / brief-communication / Cancer Research / Case-Control Studies / Colorectal cancer / Colorectal carcinoma / Colorectal Neoplasms - genetics / Diagnosis / Fundamental and applied biological sciences. Psychology / Gastroenterology. Liver. Pancreas. Abdomen / Gene Function / Genetic aspects / Genetic Linkage / Genetic Predisposition to Disease / Genetic research / Genetics of eukaryotes. Biological and molecular evolution / Genome, Human / Genomics / Genotype / Genotype & phenotype / Health risks / Human Genetics / Humans / Identification and classification / Medical sciences / Physiological aspects / Polymorphism, Single Nucleotide / Risk Factors / Single nucleotide polymorphisms / Smad7 Protein - genetics / Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / Tumors

2007

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A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

2007

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2007

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Journal Article

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

Carvajal-Carmona, Luis,

Rowan, Andrew,

Lubbe, Steven,

Houlston, Richard S,

Webb, Emily,

Gray, Richard,

Peto, Julian,

Fielding, Sarah,

Spain, Sarah,

Qureshi, Mobshra,

Barclay, Ella,

Sieber, Oliver,

Gorman, Maggie,

Papaemmanuil, Elli,

Tomlinson, Ian,

Cazier, Jean-Baptiste,

Sullivan, Kate,

Jaeger, Emma,

Wood, Wendy,

Howarth, Kimberley,

Penegar, Steven,

Martin, Lynn,

Domingo, Enric,

Pittman, Alan M,

Vijayakrishnan, Jayaram,

Kerr, David,

Broderick, Peter,

Sellick, Gabrielle,

Kemp, Zoe,

Chandler, Ian,

Teixeira, Ana

2007

Overview

To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant ( P trend = 1.0 × 10 −12 ).

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

Agriculture

/ Alleles

/ Animal Genetics and Genomics

/ Biological and medical sciences

/ Biomedical and Life Sciences

/ Biomedicine

/ brief-communication