Asset Details
Do you wish to reserve the book?
The role of dopamine in the brain - lessons learned from Parkinson's disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The role of dopamine in the brain - lessons learned from Parkinson's disease
Do you wish to request the book?
The role of dopamine in the brain - lessons learned from Parkinson's disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The role of dopamine in the brain - lessons learned from Parkinson's disease
2019
Overview
Parkinson's disease causes a characteristic combination of motor symptoms due to progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta. The core impairment of dopaminergic neurotransmission has motivated the use of functional magnetic resonance imaging (fMRI) in patients with Parkinson's disease to elucidate the role of dopamine in motor control and cognition in humans. Here we review the main insights from functional brain imaging in Parkinson's disease. Task-related fMRI revealed many disease-related alterations in brain activation patterns. However, the interpretation of these findings is complicated by the fact that task-dependent activity is influenced by complex interactions between the amount of dopaminergic neurodegeneration in the task-relevant nuclei, the state of medication, genetic factors and performance. Despite these ambiguities, fMRI studies in Parkinson's disease demonstrated a central role of dopamine in the generation of movement vigour (bradykinesia) and the control of excessive movements (dyskinesia), involving changes of both activity and connectivity of the putamen, premotor and motor regions, and right inferior frontal gyrus (rIFG). The fMRI studies addressing cognitive flexibility provided convergent evidence for a non-linear, U-shaped, relationship between dopamine levels and performance. The amount of neurodegeneration in the task-relevant dopaminergic nuclei and pharmacological dopamine replacement can therefore move performance either away or towards the task-specific optimum. Dopamine levels also strongly affect processing of reward and punishment for optimal learning. However, further studies are needed for a detailed understanding of the mechanisms underlying these effects.
•Parkinson's disease (PD) results in neurodegeneration of dopaminergic neurons.•Functional MRI in patients examines the role of dopamine in the human brain.•Evidence point to a central role of dopamine in securing movement vigour.•Dopamine levels and cognitive performance show an inverse U-shape relationship.•Dopamine is central for learning from rewards and punishments.
Publisher
Elsevier Inc,Elsevier Limited,Elsevier
Subject
/ Cognitive Dysfunction - diagnostic imaging
/ Cognitive Dysfunction - etiology
/ Cognitive Dysfunction - metabolism
/ Cognitive Dysfunction - physiopathology
/ Dopamine
/ Executive Function - physiology
/ Functional magnetic resonance imaging
/ Humans
/ Hyperkinesis - diagnostic imaging
/ Hyperkinesis - physiopathology
/ Hypokinesia - diagnostic imaging
/ Hypokinesia - physiopathology
/ Parkinson Disease - complications
/ Parkinson Disease - diagnostic imaging
/ Parkinson Disease - metabolism
/ Parkinson Disease - physiopathology
/ Putamen
/ Reward
