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头孢地嗪对免疫性肝损伤小鼠外周血T细胞亚群的影响
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Journal Article
头孢地嗪对免疫性肝损伤小鼠外周血T细胞亚群的影响
2008
Overview
目的观察头孢地嗪对免疫性肝损伤小鼠外周血T细胞亚群的调节作用。方法采用卡介苗联合脂多糖诱导法建立免疫性肝损伤的小鼠模型；将造模成功的免疫性肝损伤小鼠随机分为胸腺肽组、头孢地嗪大、中、小剂量组、头孢曲松组和生理盐水组，连续给药7d，同时以正常小鼠作为对照组；采用免疫荧光染色技术，经流式细胞仪对小鼠的外周血T细胞亚群进行检测。结杲免疫性肝损伤合并败血症小鼠的CD3^＋（％）、CD4^＋（％）和CD8^＋（％）均明显低于正常小鼠，而头孢地嗪可有效地提高免疫性肝损伤合并败血症小鼠的CD3^＋（％）、CD4^＋（％）和CD4^＋／CD8^＋。结论头孢地嗪可通过调整CD4^＋和CD8^＋之间的平衡，有效地提高机体的免疫功能。
