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Recent insights into cutaneous immunization: How to vaccinate via the skin
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Recent insights into cutaneous immunization: How to vaccinate via the skin
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Journal Article
Recent insights into cutaneous immunization: How to vaccinate via the skin
2015
Overview
•Various active and passive approaches available for cutaneous immunization.•Cutaneous immunization provides the potential to induce humoral, cellular and mucosal immune responses.•Adjuvants affect the type of immunity upon cutaneous immunization.•DNA vaccination successfully performed employing different cutaneous administration strategies.
Technologies and strategies for cutaneous vaccination have been evolving significantly during the past decades. Today, there is evidence for increased efficacy of cutaneously delivered vaccines allowing for dose reduction and providing a minimally invasive alternative to traditional vaccination. Considerable progress has been made within the field of well-established cutaneous vaccination strategies: Jet and powder injection technologies, microneedles, microporation technologies, electroporation, sonoporation, and also transdermal and transfollicular vaccine delivery. Due to recent advances, the use of cutaneous vaccination can be expanded from prophylactic vaccination for infectious diseases into therapeutic vaccination for both infectious and non-infectious chronic conditions. This review will provide an insight into immunological processes occurring in the skin and introduce the key innovations of cutaneous vaccination technologies.
Publisher
Elsevier Ltd
