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他汀类调脂药神经肌肉系统不良反应
by
黄一宁
in
神经系统疾病
/ 综述
/ 肌疾病
/ 降血脂药
2016
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他汀类调脂药神经肌肉系统不良反应
by
黄一宁
in
神经系统疾病
/ 综述
/ 肌疾病
/ 降血脂药
2016
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Journal Article
他汀类调脂药神经肌肉系统不良反应
2016
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Overview
他汀类调脂药是目前应用最广泛的调脂药物,通过抑制内源性胆固醇合成过程中的3-羟基-3-甲基戊二酰辅酶A还原酶(HMGCR)而发挥药理学作用。他汀类调脂药可以减少心脑血管疾病的风险,目前全球每年约30×106例患者服用他汀类调脂药,其中约10%因神经肌肉系统不良反应而停药。本文拟对他汀类调脂药的神经肌肉系统不良反应,如肌肉毒性、神经毒性、重症肌无力(MG)等进行简要概述。
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