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肥胖儿童早期肾脏损害指标的相关因素分析
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肥胖儿童早期肾脏损害指标的相关因素分析
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Journal Article
肥胖儿童早期肾脏损害指标的相关因素分析
2016
Overview
目的分析肥胖儿童早期肾脏损害的敏感指标及影响肾损害的相关因素。方法按照尿中微量白蛋白（MAU）的水平将肥胖儿童分为肥胖肾损组、肥胖非肾损组,并选择正常体重儿童作为对照组,比较不同组间尿β2微球蛋白（β2MG）、尿白蛋白（ALB）、尿IV胶原纤维蛋白（CIV）,尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）的水平。并用多元线性回归进一步分析肾脏损害的危险因素。结果单因素方差分析发现,尿MAU、CIV在3组间比较均具有统计学差异（P〈0.05）,进一步用LSD检验发现CIV两组间比较均具有统计学差异（P〈0.05）,尿MAU在肥胖非肾损组与肥胖肾损组间比较具有统计学差异（P〈0.05）,在对照组与肥胖非肾损组间比较无统计学差异（P〉0.05）;多元线性回归分析显示,收缩压标准化分值（SDS-SBP）、BMI标准化分值（SDS-BMI）、CIV、TNF-α与尿MAU显著相关。结论肥胖儿童主要以肾小球损害为主;CIV预测肾小球损害是更灵敏的指标;SDS-SBP、SDS-BMI、CIV、TNF-α为儿童肥胖肾脏损害的危险因素。
Publisher
西安交通大学第二附属医院儿科,陕西西安,710004
Subject
