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Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome
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Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome
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Journal Article
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome
2021
Overview
The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory
1
,
2
, neurologic
3
and neoplastic diseases
4
. Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain
5
–
11
. Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition
11
. In a genome-wide association analysis of 8,956 German individuals, we identified 38 genetic loci to be associated with single bacteria and overall microbiome composition. Further analyses confirm the identified associations of ABO histo-blood groups and FUT2 secretor status with
Bacteroides
and
Faecalibacterium
spp. Mendelian randomization analysis suggests causative and protective effects of gut microbes, with clade-specific effects on inflammatory bowel disease. This holistic investigative approach of the host, its genetics and its associated microbial communities as a ‘metaorganism’ broaden our understanding of disease etiology, and emphasize the potential for implementing microbiota in disease treatment and management.
Genome-wide association analysis of 8,956 German individuals identifies 38 genetic loci associated with single bacteria and overall microbiome composition.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 45/61
/ 45/77
/ 631/208
/ 631/326
/ ABO Blood-Group System - genetics
/ Animal Genetics and Genomics
/ Biomedical and Life Sciences
/ Fucosyltransferases - genetics
/ Galactoside 2-alpha-L-fucosyltransferase
/ Gastrointestinal Microbiome - genetics
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Germany
/ Humans
/ Letter
/ Mendelian Randomization Analysis
