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Targeting mitochondria: restoring the antitumor efficacy of exhausted T cells
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Journal Article
Targeting mitochondria: restoring the antitumor efficacy of exhausted T cells
2024
Overview
Immune checkpoint blockade therapy has revolutionized cancer treatment, but resistance remains prevalent, often due to dysfunctional tumor-infiltrating lymphocytes. A key contributor to this dysfunction is mitochondrial dysfunction, characterized by defective oxidative phosphorylation, impaired adaptation, and depolarization, which promotes T cell exhaustion and severely compromises antitumor efficacy. This review summarizes recent advances in restoring the function of exhausted T cells through mitochondria-targeted strategies, such as metabolic remodeling, enhanced biogenesis, and regulation of antioxidant and reactive oxygen species, with the aim of reversing the state of T cell exhaustion and improving the response to immunotherapy. A deeper understanding of the role of mitochondria in T cell exhaustion lays the foundation for the development of novel mitochondria-targeted therapies and opens a new chapter in cancer immunotherapy.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Biomedical and Life Sciences
/ Cancer
/ Fatigue
/ Humans
/ Lymphocytes, Tumor-Infiltrating - cytology
/ Lymphocytes, Tumor-Infiltrating - drug effects
/ Lymphocytes, Tumor-Infiltrating - immunology
/ Lymphocytes, Tumor-Infiltrating - metabolism
/ Oncology
/ Reactive Oxygen Species - metabolism
/ Review
/ T cells
/ T-Lymphocytes - drug effects
