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肿瘤转移抑制基因-1在食管鳞癌组织及食管癌EC109细胞中的表达及意义
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Journal Article
肿瘤转移抑制基因-1在食管鳞癌组织及食管癌EC109细胞中的表达及意义
2017
Overview
目的 探讨肿瘤转移抑制基因-1（TMSG-1）在食管鳞癌（ESCC）组织及食管癌EC109细胞中的表达及意义。方法 采用SP免疫组织化学染色法检测136例ESCC及37例正常食管黏膜组织中TMSG-1蛋白的表达情况,分析TMSG-1与ESCC患者临床病理指标的关系;培养人食管癌EC109细胞并用常用化疗药物顺铂（CDDP）干预,同时设对照组,采用MTT法检测细胞增殖抑制率,半定量RT-PCR法检测细胞TMSG-1的表达情况。结果 TMSG-1在ESCC和正常食管黏膜的阳性率分别为52.2%（71/136）、94.6%（35/37）,差异具有统计学意义（P〈0.05）。TMSG-1的异常表达与ESCC组织学分级、患者的TNM分期、淋巴结转移情况相关。顺铂干预组EC109细胞的增殖抑制率较对照组显著增高,差异具有统计学意义（P〈0.01）。RT-PCR结果显示,干预组EC109细胞TMSG-1的mRNA表达明显高于对照组（P〈0.01）。结论 TMSG-1的异常表达与ESCC的发展及转移相关,可作为较为理想的肿瘤标志物辅助诊断并指导临床治疗。
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