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肾清饮对腺嘌呤致肾间质纤维化大鼠肾脏TGF-β1及TIMP-1表达的影响
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肾清饮对腺嘌呤致肾间质纤维化大鼠肾脏TGF-β1及TIMP-1表达的影响
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Journal Article
肾清饮对腺嘌呤致肾间质纤维化大鼠肾脏TGF-β1及TIMP-1表达的影响
2010
Overview
目的探讨肾清饮抑制肾间质纤维化的可能机制。方法采用腺嘌呤灌胃法建立大鼠肾间质纤维化动物模型,并给予肾清饮和盐酸苯那普利干预治疗,作肾脏病理学检查,并以免疫组化和RT-PCR方法分别检测大鼠肾脏转化生长因子β1（TGF-β1）、金属蛋白酶组织抑制物-1（TIMP-1）的表达。结果各肾清饮干预组肾组织肾间质纤维化程度轻于模型对照组,免疫组化和RT-PCR检测的肾脏TGF-β1、TIMP-1的表达量均少于模型对照组（P〈0.05）。结论肾清饮可通过减少肾组织TGF-β1、TIMP-1的表达,抑制肾间质纤维化的进展。
Publisher
西安交通大学医学院第一附属医院肾内科,陕西西安,710061%北京天坛医院肾内科,北京,100050
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