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利培酮所致的体质量、瘦素、瘦素基因变化与精神症状的相关性
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利培酮所致的体质量、瘦素、瘦素基因变化与精神症状的相关性
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Journal Article
利培酮所致的体质量、瘦素、瘦素基因变化与精神症状的相关性
2016
Overview
目的 探讨抗精神病药利培酮治疗后的体质量增加与血浆瘦素水平及瘦素基因启动子区-2548G/A多态性和精神症状减分率间有无相关性。方法 利培酮单药治疗10周,测定66例患者治疗前后体质量指数（BMI）、腹围及血浆瘦素浓度;PCR-RFLP方法分析66例精神分裂症或分裂样精神病患者瘦素基因启动子区-2548G/A多态性;PANSS量表评定患者治疗前后精神症状;分析体质量指标变化值与血浆瘦素浓度、瘦素基因多态性和PANSS减分率的相关性。结果 治疗后患者体质量指标均有显著性增加（P=0.000,0.002）;平均BMI变化为（1.52±1.28）kg/m^2,腹围为（4.08±4.32）cm。此外,血浆瘦素水平在治疗期间也有增加,但没有统计学差异（P=0.102）。基础体质量指标显著影响体质量指标变化值,差异有显著性;不同治疗时期的体质量指标显著影响相应时期的血浆瘦素水平和瘦素水平变化值,瘦素基因多态性和PANSS减分率对血浆瘦素水平或瘦素水平变化值的影响的差异均没有显著性（P〉0.05）。结论 瘦素基因-2548G/A多态性不是利培酮所致的体质量增加的主要遗传因素;体质量增加不是利培酮临床疗效的指标。
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