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Implications of the discovery of brain lymphatic pathways
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Journal Article
Implications of the discovery of brain lymphatic pathways
2015
Overview
The lymphatic system performs essential physiological functions for protein homeostasis and immune surveillance; hence, the apparent absence of conventional lymphatic vessels from the CNS has remained a persistent mystery of neuroscience, particularly in light of the exquisite sensitivity of neurons to the composition of their extracellular environment. Genetic ablation of the dural lymphatic vasculature in mice slowed the clearance of tracers injected into the brain interstitium and prevented them from reaching the deep cervical lymph nodes, showing that the clearance of solutes from the brain interstitium was dependent upon their movement along these sinus-associated lymphatic vessels.6 One caveat shared by both studies is their implication that cervical nodes provide an intermediate way-station for fluid travelling from the brain interstitial space to the systemic circulation.
Publisher
Elsevier Ltd,Elsevier Limited
