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白细胞介素-2协同白细胞介素-18活化自然杀伤细胞活性的作用
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白细胞介素-2协同白细胞介素-18活化自然杀伤细胞活性的作用
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Journal Article
白细胞介素-2协同白细胞介素-18活化自然杀伤细胞活性的作用
2006
Overview
目的 研究白细胞介素-2（IL-2）和白细胞介素-18（IL-18）诱导自然杀伤（NK）细胞活化和抗骨髓瘤细胞活性的协同作用。方法 流式细胞仪方法检测NK细胞表面CD69的表达；阴性细胞纯化法用于获得高纯度的NK细胞；ELISA测定NK细胞培养上清液中干扰素（IFN-γ）的浓度；标准铬^51释放试验评估NK细胞杀伤骨髓瘤细胞的能力。结果 与单一应用IL-18相比，低浓度IL-2和IL-18联合应用显著提高了NK细胞的活性、分泌干扰素（IFN-γ）的水平和杀伤骨髓瘤细胞的作用。结论 低浓度IL-2具有协同IL-18活化NK细胞抗骨髓瘤细胞的作用，此结果为IL-2和IL-18联合应用治疗骨髓瘤奠定了一定的理论基础。
