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莪术二酮对肝部分切除老年小鼠术后认知功能和海马区炎性因子表达的影响
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莪术二酮对肝部分切除老年小鼠术后认知功能和海马区炎性因子表达的影响
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Journal Article
莪术二酮对肝部分切除老年小鼠术后认知功能和海马区炎性因子表达的影响
2017
Overview
目的 观察莪术二酮对肝部分切除的老年小鼠术后认知功能和海马区炎性因子表达的作用。方法 按文献报道方法建立肝部分切除老年小鼠模型,分为假手术组、手术组（模型组）及莪术二酮高、中、低剂量组（造模并药物干预）,另设空白对照组。采用Morris水迷宫评价小鼠的认知功能,采用酶联免疫吸附法检测海马组织中超氧化物歧化酶（SOD）、丙二醛（MDA）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）的水平,Western blot检测海马中NF-κB、白介素-1β（IL-1β）、白介素-6（IL-6）及肿瘤坏死因子（TNF-α）蛋白的表达。结果 手术组动物水迷宫逃逸潜伏期时间明显延长（P〈0.01）,穿台次数显著减少（P〈0.05）;与手术组相比,莪术二酮显著性缩短术后逃逸潜伏期（P〈0.05）,并增加穿台次数（P〈0.05）。肝切除术后海马组织中SOD、CAT和GSH-Px的含量均明显降低（P〈0.05）,MDA含量则明显升高（P〈0.01）。莪术二酮组SOD、CAT和GSH-Px的含量明显升高（P〈0.05）,MDA释放减少（P〈0.05）。莪术二酮组的术后NF-κB、IL-1β、IL-6及TNF-α蛋白的高表达显著抑制（P〈0.05）。结论 莪术二酮可显著改善老年小鼠部分肝切除术后认知功能障碍,其机制可能与其通过抑制海马组织中氧化应激,抑制NF-κB激活,减少炎症细胞因子IL-1β、IL-6及TNF-α的释放有关。
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