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Association of adipocytokines with lipid and glycemic profiles in women with normal weight obesity
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Association of adipocytokines with lipid and glycemic profiles in women with normal weight obesity
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Journal Article
Association of adipocytokines with lipid and glycemic profiles in women with normal weight obesity
2020
Overview
Background
Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.
Methods
Forty women with body mass index (BMI) = 18.5–24.9 kg/m
2
and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range, and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and circulating levels of leptin and vaspin were measured.
Results
The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had the higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51,
P
= 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30,
P
< 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03,
P
= 0.009) compared to the NWNO group. The serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively,
P
= 0.12). In NWO group, the serum levels of leptin had positive correlation with FBS (
r
= 0.45,
P
= 0.02), insulin (
r
= 0.51,
P
= 0.008), and HOMA-IR (
r
= 0.46,
P
= 0.02) and vaspin concentration was associated with insulin (
r
= 0.36,
P
= 0.02) and HOMA-IR (r = 0.30,
P
= 0.06), positively.
Conclusion
It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher concentrations of leptin and vaspin in the NWO group were associated with glycemic profile.
