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ALOX15基因单核苷酸多态性与冠心病遗传易感性的相关性
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Journal Article
ALOX15基因单核苷酸多态性与冠心病遗传易感性的相关性
2016
Overview
目的探讨中国陕西地区汉族人群花生四烯酸15-脂加氧酶（arachidonate 15-lipoxygenase,ALOX15）基因多态性是否是冠心病（coronary heart disease,CHD）的遗传易感因素,从而为该病的早期诊断和预防提供相关依据。方法应用聚基质辅助激光解吸附电离飞行时间质谱方法（matrix-assisted laser desorption/ionization-time of flight,MALDI-TOF）,检测105例CHD患者（CHD组）和75例年龄及性别相匹配的非冠心病者（对照组）的ALOX15基因3个位点rs916055、rs2619112、rs2664593的单核苷酸多态性（single nucleotide polymorphisms,SNPs）,判定其基因型并统计各基因型及等位基因的频率。结果 rs916055A/G的基因型以及等位基因频率在CHD组和对照组间有统计学差异（P=0.000 1,P=0.000 1）;rs2619112A/G的基因型以及等位基因频率在CHD组和对照组间无统计学差异（P=0.134 2,P=0.143 8）;rs2664593C/G的基因型在CHD组和对照组间有统计学差异（P=0.002 7）,等位基因频率在CHD组和对照组间无统计学差异（P=0.537 1）;应用Logistic回归分析调整了其他相关因素后显示,rs916055位点携带A等位基因为CHD发病的独立危险因素。结论 rs916055位点可能与CHD发病相关,A等位基因可能是CHD的遗传易感基因。
Publisher
西电集团医院心内科,陕西西安,710077%西安交通大学第二附属医院心内科,陕西西安,710004
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