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SAHA对胃癌MGC-803细胞增殖与周期及凋亡的影响
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SAHA对胃癌MGC-803细胞增殖与周期及凋亡的影响
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Journal Article
SAHA对胃癌MGC-803细胞增殖与周期及凋亡的影响
2017
Overview
摘要：目的研究组蛋白去乙酰化酶抑制剂（SAHA）对胃癌细胞株MGC-803增殖、凋亡及周期的影响。方法MTT比色法观察不同药物浓度SAHA作用于培养胃癌细胞株MGC-803时的增殖变化，初步选取药物作用48h时的合适药物浓度，进一步用流式细胞术检测1、2μmol／L SAHA对MGC-803细胞凋亡及周期的影响，Westernblot检测乙酰化组蛋白3、4及cyclinD1蛋白的表达情况。结果与正常对照组相比，sAHA处理组细胞增殖能力降低，凋亡率升高，细胞周期内G1期比率升高，差异均具有统计学意义（P〈0．05）；Westernblot检测结果显示，与正常对照组相比，SAHA处理组的乙酰化组蛋白3、乙酰化组蛋白4升高，而eyclinD1含量降低，差异均具有统计学意义（P〈0．01）。结论组蛋白去乙酰化酶抑制剂SAHA可以抑制MGC-803细胞增殖，通过G1-S期阻滞抑制细胞周期，促进细胞凋亡，可能与促进乙酰化组蛋白3及乙酰化组蛋白4的表达增多有关。
Publisher
锦州医科大学,辽宁锦州,121000%锦州医科大学附属第一医院,辽宁锦州,121000
Subject
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