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多发性硬化患者外周血白细胞介素-4、10和干扰素-γ分泌临床研究
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多发性硬化患者外周血白细胞介素-4、10和干扰素-γ分泌临床研究
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Journal Article
多发性硬化患者外周血白细胞介素-4、10和干扰素-γ分泌临床研究
2014
Overview
目的从单个T细胞水平探讨多发性硬化患者病程不同阶段外周血细胞因子分泌变化,以为鉴别诊断和判断病情提供线索。方法采用酶联免疫斑点试验（ELISPOT）检测外周血单个核细胞在自分泌状态下和经外源性抗原（刀豆蛋白A、髓鞘碱性蛋白、乙酰胆碱受体）刺激后,外周血白细胞介素（IL）-4、10和干扰素-γ（IFN-γ）分泌变化。结果与正常对照组和其他非免疫性神经疾病组相比,多发性硬化组患者经髓鞘碱性蛋白刺激后外周血IL-4、IL-10和IFN-γ分泌水平升高（均P=0.000）,其中髓鞘碱性蛋白特异性IFN-γ分泌水平在急性发作期或加重期高于稳定期（P=0.002）,而IL-4和IL-10则无明显改变。结论在外源性抗原髓鞘碱性蛋白刺激下,采用ELISPOT法检测多发性硬化患者血清IL-4、IL-10和IFN-γ特异性分泌水平,具有鉴别诊断和判断疾病进展阶段的作用。
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