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综合防治措施对大剂量阿糖胞苷巩固治疗小儿白血病不良反应的预防作用
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Journal Article
综合防治措施对大剂量阿糖胞苷巩固治疗小儿白血病不良反应的预防作用
2015
Overview
目的探讨综合防治措施在大剂量阿糖胞苷巩固治疗小儿白血病过程中对不良反应预防及治疗作用。方法将2010年1月-2013年12月在河南科技大学第一附属医院新区医院接受以阿糖胞苷为主的综合用药治疗的30例小儿白血病患者分为2组,A组给予综合防治措施对治疗过程中的不良反应进行预防和治疗,B组给予常规的治疗措施。对比其不良反应发生情况,分析综合防治措施在不良反应预防及治疗中的作用。结果 A组15例患者共进行治疗50次,B组15例患者共进行治疗46次,在巩固治疗中出现的主要不良反应为药物热以及皮疹、神经系统毒性、消化系统毒副作用、骨髓抑制等,其中综合防治组神经系统毒性、消化系统毒副作用、药物热、皮疹及感染等不良反应的发生率均明显低于常规治疗组,差异有统计学意义;综合防治组骨髓抑制的发生率与常规治疗组无明显差异,但骨髓抑制分级明显低于常规治疗组,差异有统计学意义。结论综合防治措施应用于大剂量阿糖胞苷巩固治疗小儿白血病能够有效降低治疗过程中皮疹、药物热、神经系统毒性、消化系统毒副作用、感染等不良反应的发生率,降低骨髓抑制的严重程度,保证患儿安全地完成综合治疗。
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